Emergency services were called shortly before 2pm on Tuesday, before the teenager was taken to hospital, where he later died.
Scotland Yard said no arrests had been made and they were continuing their investigations at the scene in Edgware Road, near the junction with Church Street in Westminster.
Home UK World Politics US Ocean Rescue Science & Tech Business Ents & Arts Travel Offbeat Analysis Opinion Sky Views Videos Weather Watch Live Teen stabbed to death near college in busy part of Westminster Police are urging witnesses “to do the right thing and get in touch with what they saw” before, during or after the attack. Fill 2 Copy 11 Created with Sketch. Wednesday 11 September 2019 09:04, UK
Detective Chief Inspector Andy Partridge from the Metropolitan Polices Specialist Crime Command said the attack took place near a college where "many young people would have been on their break".
Mr Partridge added: "This awful attack took place in broad daylight in a busy part of central London.
"A teenager with his whole life ahead of him has been taken away from his family who have been left heartbroken.
"We need them to do the right thing and get in touch right away with what they saw, along with any images or moving footage captured before, during or after the attack."
News Corp is a network of leading companies in the worlds of diversified media, news, education, and information services.
Manhunt launched after lad, 17, brutally knifed to death outside London KFC
Anyone with information about the killing is asked to contact police on 101 quoting CAD 3755/10Sept or to call Crimestoppers anonymously on 0800 555 111.
Emergency responders found the teen with multiple stab injuries and rushed him to hospital where he later died