The Seagulls are just two points clear of the Premier League relegation zone after Tuesdays 2-0 loss at home to Cardiff.
Albion have failed to score in their last five games and meet a Wolves side who still have their sights set on a seventh-placed finish and with it a possible Europa League place.
In the meeting between the teams earlier this season, Brighton striker Glenn Murray got the only goal of the game.
Raul Jimenez has starred in his first season in the Premier League with 12 goals and seven assists, while Diogo Jota has seven goals and four assists.
Defender Willy Boly has chipped in with four goals, while Ivan Cavaleiro, Ruben Neves and Matt Doherty all have three each.
Neves and Joao Moutinho pull the strings in the middle of the park, with Moutinho having provided eight assists this season.
Wolves defensive record is the sixth best in the division and keeper Rui Patricio has kept six clean sheets.
Currently eighth, Wolves are still right in the hunt to finish seventh which could be enough to seal a Europa League place for next season.
Despite a 3-1 defeat at Southampton last time out, Wolves boss Nuno Espirito Santo is unlikely to make too many changes to his starting line-up.
Likely line-up: Rui Patricio; Bennett, Coady, Boly; Doherty, Dendoncker, Moutinho, Neves, Otto; Jimenez, Otto. Subs (from): Ruddy, Saiss, Cavaleiro, Costa, Gibbs-White, Vinagre, Traore, Kilman, Ennis.
Chris Hughtons side are two points above Cardiff with a game in hand and a superior goal difference (-21 to -33).
The momentum, however, appears to be with the Welshmen after their 2-0 win at the Amex on Tuesday and a slightly easier run-in.